About The Book


Skin cancer, including melanoma and nonmelanoma cancers, is the most common malignancy in the United States and constitutes an evolving global epidemic. Although the majority of these lesions occur on the head and neck, the treatment of skin cancer crosses numerous medical and surgical specialties. Unfortunately, the preponderance of treatment occurs in a disjointed fashion as dermatologists, surgeons, primary care providers, and radiation oncologists endeavor to cure patients within their own spheres. Consequently, aggressive malignancies are often identified late, and patient outcomes are unsatisfactory, with potentially avoidable morbidity and mortality.

Dr. Randal Weber, Professor and Chairman of Head and Neck Surgery at the University of Texas M.D. Anderson Cancer Center and a world-renowned leader in the treatment of aggressive cutaneous malignancy, and Dr. Brian A. Moore have assembled a panel of current and emerging leaders in comprehensive oncologic care to clarify the challenges and advances in treating skin cancer of the head and neck. Unlike other anatomic regions, the complex anatomy, unique functions, and aesthetic import of head and neck structures demand great technical expertise and a collaborative approach to meet the expectations of patients.

For the first time, a true multidisciplinary approach to cutaneous malignancy of the head and neck is presented, as international experts in head and neck surgical oncology, dermatology, Mohs micrographic surgery, plastic and reconstructive surgery, radiation oncology, and medical oncology present state-of-the-art techniques and promising horizons in the treatment of cutaneous malignancy of the head and neck. Whether in primary care or a specialty practice, this text should prove invaluable to any practitioner who treats patients with skin cancer of the head and neck.

This is the only textbook on this subject that comprehensively addresses patient management – from diagnosis, treatment (in all forms, including chemotherapy and radiation), and reconstruction.

This book makes preparation for actual patient care or presentations simpler and easier; currently, someone wanting to study this field would have to get articles, a head and neck surgery text, and a facial plastic/reconstruction text to gather all the information that is presented here.

This book is suitable for ENT surgeons, plastic surgeons, general surgical oncologists, dermatologists, and even radiation/medical oncologists in endemic areas who treat patients with aggressive cutaneous malignancies. Each chapter has information that will be valuable to both seasoned practitioners and residents in training.

About The Authors

Dr. Weber is an internationally recognized surgeon and expert in the treatment of patients with head and neck cancer. He currently serves as Professor and Chairman of the Department of Head and Neck Surgery at The University of Texas MD Anderson Cancer Center in Houston, Texas, and is the recipient of the Hubert L. and Olive Stringer Distinguished Professorship in Cancer Research.
Dr. Weber was awarded an M.D. from the University of Tennessee Health Science Center College of Medicine. After completing a surgery internship at the National Naval Medical Center in Bethesda, Maryland, Dr. Weber completed residencies in both surgery and otolaryngology at Baylor College of Medicine in Houston, Texas. He then received specialized training in head and neck surgical oncology, completing a two-year fellowship at MD Anderson Cancer Center. After he completed his training, Dr. Weber was appointed to the faculty of the Department of Head and Neck Surgery at MD Anderson, with a joint appointment to the Department of Otolaryngology at Baylor College of Medicine. He went on to serve as the Gabriel Tucker Professor and Vice Chair of the Department of Otolaryngology—Head and Neck Surgery at the Hospital of the University of Pennsylvania in Philadelphia, and later returned to MD Anderson to accept the post as Chairman. He holds a joint appointment as Professor in the Department of Radiation Oncology at MD Anderson and is an Adjunct Professor at Baylor College of Medicine.
Committed to oncologic research, cancer prevention, and the education of future leaders in head and neck oncology, Dr. Weber is active in clinical research investigating various head and neck cancers, including cutaneous malignancies. He remains closely involved in the development and oversight of several training fellowships and in the clinical and laboratory training of young physician–scientists. He has been the honored guest lecturer and visiting professor at multiple institutions in the United States and internationally, has led numerous courses and seminars, and has presented and moderated more than 130 lectures, invited lectures, and panel discussions. He has served as President of the Society of University Otolaryngologists—Head and Neck Surgeons, the American Radium Society, and the American Head and Neck Society. He was appointed Director of the American Board of Otolaryngology for the 2007–2014 term.

Dr. Weber is a prolific author in the field, having published more than 200 articles and invited articles, 40 book chapters, and two books focused on the basic science and the surgical and clinical treatment for head and neck cancer. Volumes include Head and Neck Cancer: Basic and Clinical Aspects (Kluwer Academic Publishers, The Netherlands, 1995) and Basal and Squamous Cell Skin Cancer of the Head and Neck (Williams & Wilkins, Philadelphia, 1996). He is the immediate past Editor in Chief of Head & Neck: Journal for the Sciences and Specialties of the Head and Neck, a position he held for more than 13 years. He is currently an Associate Editor for Cancer and serves on the editorial boards of CancerJournal of Clinical OncologyAmerican Journal of RhinologyHead & Neck, and Clinical Medicine: Ear, Nose and Throat. Dr. Weber’s clinical interests are nonmelanoma skin cancer, thyroid cancer, and therapeutic strategies for organ preservation.

Dr. Moore is an emerging national leader in head and neck surgery and a recognized expert in head and neck surgical oncology and reconstructive microsurgery. After serving in the United States Air Force as Chief of Surgical Services at Eglin AFB in Florida, Dr. Moore joined Ochsner Medical Center in New Orleans as Chief of Head and Neck Surgery and Vice-Chairman of the Department of Otolaryngology.

A native of Bowling Green, Kentucky, and a graduate of Tulane University, he received his MD from Tulane University in 1998. He completed a surgical internship and residency in Otolaryngology- Head and Neck Surgery at Vanderbilt University, before becoming the first otolaryngologist to complete a combined two-year fellowship in Head and Neck Surgical Oncology and Reconstructive Microsurgery at the University of Texas MD Anderson Cancer Center.

As Chief of Surgical Services at Eglin Air Force Base, his efforts have focused on developing a multidisciplinary approach to head and neck cancer in a community setting. He remains active in medical student and resident education through his efforts as a Clinical Assistant Professor in the Department of Otolaryngology-Head and Neck Surgery at Tulane University School of Medicine.

An invited lecturer at multiple institutions, both civilian and military across the Unites States, he is active in clinical research in cutaneous malignancy of the head and neck, thyroid disease, and reconstruction of the head and neck, and has more than 15 peer-review publications, numerous book chapters, and several invited articles, and serves as a reviewer for several leading otolaryngology journals, including Head and Neck.

Dr. Moore’s clinical interests include advanced skin malignancy, melanoma, thyroid and parathyroid disease, tumors of the upper aerodigestive tract, and microsurgical reconstruction of the head and neck.


Table Of Contents

1. Anatomy of the Skin and Draining Lymphatics
Randal Weber and Richard Wein

2. Clinical Evaluation of the Patient with Cutaneous Malignancy
Brian Moore,Randal Weber, and Christina J. Yang

3. Psychosocial Impact of Skin Cancer Treatment
Michelle Fingeret

4. Screening, Prevention, and Surveillance
Carol R Drucker and Sharon Hymes

5. Ultraviolet Carcinogenesis and Immune Suppression
Stephen Ullrich

6. Histopathology of Nonmelanoma Skin Cancer
Carlos Torres-Cabala, Jonathan L. Curry, and Victor G. Prieto

7. Epidemiology, Staging, Prognosis of Nonmelanoma Skin Cancer
Carsten Palme, Mark C. Smith, and Michael J. Veness

8. Aggressive Nonmelanoma Skin Cancer of the Head and Neck
Nandita Guha-Thakurta, Christian P. Hasney, Brian A. Moore, and Randal S. Weber

9. Surgical Management of Locoregional Disease
Stephen Y. Lai and Randal S. Weber

10. Special Considerations: Periauricular Lesions
Paul Gidley

11. Periorbital and Ocular Adnexal Cutaneous Lesions: Special Considerations
Bita Esmaeli and Aaron Savar

12. Special considerations: Neurosurgical Management
Franco DeMonte

13. Radiotherapy for Cutaneous Squamous and Basal Cell Carcinoma
Robert J. Amdur, Nancy Mendenhall and William Mendenhall

14. Photodynamic Therapy for Non-Melanoma Skin Cancer
Joseph Housel and Natalie Zeitouni

15. Therapeutic Horizons for Cutaneous Malignancies
Michael Kupferman, Eben Rosenthal and Randal Weber

16. Adnexal Tumors of the Head and Neck
Amy Hessell

17. Merkel Cell Carcinoma
Cecelia Schmalbach

18. Dermatofibrosarcoma protuberans of the Head and Neck Region
Thomas D. Shellenberger and Erich M. Sturgis

19. Angiosarcoma of the Head and Neck
Amy Hessell

20. Melanoma Epidemiology, Staging, Prognosis
Carol Bradford and Audrey Erman

21. Molecular Biology and Genetics of Melanoma/ Mechanisms of Spread
Meenhard Herlyn, Helmut Schaider and Susan Zabierowski

22. Immunobiology and Immunotherapy of melanoma
Johnny Kao, Lauren Levy and Andrew Sikora

23. Histology of Melanoma and Precursor Lesions
A.Hafeez Diwan, Doina Ivan and Victor G. Prieto

24. Local Management of Melanoma
Benjamin L. Judson and Dennis H. Kraus

25. Regional Management of Melanoma in the Clinically Node Negative Neck
Matthew T. Ballo, Jeffrey E. Gershenwald, Laurie Loevner and Jeffrey N. Myers

26. Regional Management of Melanoma in the Clinically Node-Positive Neck
Paul Jonas, Ruth Jonas and Jesus E. Medina

27. Role of Chemotherapy, Biochemotherapy, and Targeted Systemic Therapies in the Treatment of Metasataic Melanoma
Richard W. Joseph, Kevin Kim and Sapna P. Patel

28. Ocular Melanoma
Dan S. Gombos

29. Mucosal melanoma
Sapna P. Patel

30. Microscopically Oriented Histographic Surgery (MOHS): Indications, Principles, and Technique
Michael Migden

31. Mohs Surgery: Adjunctive Treatment of Skin Cancer
Kimberly Thomas and Valencia Thomas

32. Principles of Head and Neck Cutaneous Reconstruction
Roxanna Baratelli and Brain A. Moore

33. Nasal reconstruction
Elisabeth K. Beahm, Matthew M. Hanasono and Robert L. Walton

34. Lip reconstruction
Howard N. Langstein and Hani Sbitany

35. Periorbital reconstruction
Stephen R. Klapper, James R. Patrinely and Charles S. Soparkar

36. Auricular Reconstruction
Sean Boutros, Charles E. Butler and Lok Huei Yap

37. Scalp Reconstruction
Melissa A. Crosby

38. Reconstruction of the Cheek
Anuja K. Antony and Babak J. Mehrara

39. Prosthetic Rehabilitation of the Head and Neck
Mark S. Chambers, Theresa M. Hofstede, Rhonda F. Jacob, Jack W. Martin, Patricia C. Montgomery and Peggy J. Wesley


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