About The Book

Manual of Allergy and Clinical Immunology for Otolaryngologists presents the most up-to-date knowledge related to allergy and immunology and is directed toward the unique needs of otolaryngologists. Many of the clinical conditions treated by otolaryngologists have an allergic or immunologic pathogenesis–including sinusitis, rhinitis and otitis–and otolaryngologists are often required to use allergic methodology to treat these conditions. This text serves as a resource for physicians in the diagnosis and management of allergic aspects of common ENT problems.

This must-have reference begins with an introduction to the fundamental immunologic processes necessary to understand allergic mechanisms and diseases and goes on to address food and drug allergies, anaphylaxis, immune deficiencies, occupational allergic diseases, and tumor immunology among other topics. Otolaryngologists across all specialties as well as residents will benefit from the text’s presentation of the most important aspects of each topic in a concise, easy-to-reference format.

From the Foreword

“The fields of allergy, immunology, and otolaryngology are inextricably linked. Immunologic dysregulation is recognized to be the underpinning of a wide variety of diseases of the head and neck, and on a daily basis the practicing otolaryngologist must draw upon principles of allergy and immunology in the diagnosis and treatment of patients. For example, it is a rare patient presenting with a sinonasal complaint in whom consideration of allergic etiologies is not relevant. The otolaryngologist must also have a strong understanding of autoimmune illnesses to recognize the unique array of potential head and neck manifestations associated with autoimmune disease. Equally important, a deeper understanding of immunopathology may be the key to unlocking the mechanisms of major diseases ranging from chronic rhinosinusitis to head and neck cancer. Thus, it is imperative for the otolaryngologist to master principles of allergy and immunology in order to provide optimal patient care.

The body of knowledge encompassed by allergy and immunology is rapidly evolving and expanding, posing a great challenge for otolaryngologists seeking to keep up with diagnostic and treatment advances in the field. This splendid textbook offers a comprehensive, multidisciplinary encapsulation of contemporary allergy and immunology for the otolaryngologist. Drs. Rosenstreich, Fried, de Vos, and Jackman have assembled an illustrious group of authors who have managed to distill the essentials of allergy and immunology for the otolaryngologist without sacrificing scientific content or detail. The reader will appreciate clear elucidation of basic science concepts and the practical translation of basic science principles to the clinical management of otolaryngologic illnesses. Diagnostic and treatment guidelines are presented with a comprehensive and pragmatic approach. This book is essential reading for all otolaryngologists, from trainees looking to grasp the breadth of overlap between otolaryngology and allergy/immunology, to seasoned otolaryngologists seeking to update their fund of knowledge with the latest developments in immunophysiology and clinical treatment. The knowledge gained from this expertly edited volume will benefit our patients tremendously.”
Peter H. Hwang, MD, Professor and Chief, Division of Rhinology and Endoscopic Skull Base Surgery, Department of Otolaryngology-Head & Neck Surgery, Stanford University School of Medicine

About The Authors

David L. Rosenstreich, MD, is professor (medicine, otolaryngology, and microbiology and immunology), chief of the Division of Allergy and Immunology, and codirector of the Severe Asthma Center for Montefiore Medical Center and the Albert Einstein College of Medicine. His research currently focuses on the effects of indoor and outdoor environmental factors on asthma and the pathophysiology and treatment of urticaria.

Dr. Rosenstreich completed medical school at New York University School of Medicine and an internal medicine residency at the Bronx Municipal Hospital Center. While at the National Institutes of Health in Bethesda, Maryland, he was a commissioned officer at the National Institute of Allergy and Infectious Diseases and a senior investigator at the National Institute of Dental and Craniofacial Research. He has also been a visiting professor at The Rockefeller University Laboratory of Cellular Physiology and Immunology.

He has been the recipient of a Public Health Service Commendation Award, the Bronx County Medical Society Excellence in Medicine Award, and is the Danziger Distinguished Scholar in Microbiology and Immunology of the Albert Einstein College of Medicine. Dr. Rosenstreich has published 196 articles, invited papers, and reviews, and has edited four books and monographs.

Marvin P. Fried, MD, FACS, completed his residency at Washington University, in St. Louis, and served in the U.S. Public Health Service. He joined the faculty at Boston University, Tufts University, then Harvard Medical School, where he was promoted to professor of otology and laryngology. He later became professor of otolaryngology-head and neck surgery and university chairman at the Albert Einstein College of Medicine and Montefiore Medical Center.

Dr. Fried has received numerous awards including the American Academy of Otolaryngology-Head and Neck Surgery Basic Research Award for residents, the Edmund Prince Fowler Award for Basic Science Research, and the Mark Award for Contributions to the Advancement of Laser Medicine and Surgery.

Dr. Fried has been president of the Society of University Otolaryngologists, the American Society for Laser Medicine and Surgery, the American Rhinologic Society, and the American Laryngological Association. He has published nearly 200 original reports, reviews, and chapters, as well as books and monographs.

Gabriele S. de Vos, MD, MSc, is assistant professor of medicine and chief of the Division of Allergy and Immunology at Jacobi Medical Center in the Bronx, New York. Her research focuses on mechanisms and efficacy of allergy immunotherapy, diagnostic methods of hypersensitvity, and the role of allergy in pediatric asthma.

Dr. de Vos completed medical school at the Technical University of Munich, Germany, and an internal medicine residency and allergy and immunology fellowship training at Jacobi and Montefiore Medical Center. She received her master of science degree at the Institute for Clinical and Translational Research at the Albert Einstein College of Medicine.

She has received the Leo M. Davidoff Society of the Albert Einstein College Medicine Award for outstanding achievement in the teaching of medical students. She has published 14 research articles and reviews, and has coauthored 3 medical textbooks.

Alexis H. Jackman, MD, FACS, is an otolaryngologist/head and neck surgeon with a subspecialty in rhinology/endoscopic sinus and skull base surgery. She earned her medical degree with distinction from George Washington University, and completed her internship in general surgery and residency in otolaryngology-head and neck surgery at the New York University School of Medicine.

Dr. Jackman completed her fellowship in rhinology and endoscopic sinus and skull base surgery at the University of Pennsylvania School of Medicine. She is a recipient of the Ruth L. Kirschstein National Research Service Award from the National Institutes of Health. Dr. Jackman has been awarded multiple honors, and has authored numerous research and clinical publications in the field of otolaryngology and endoscopic sinus and skull base surgery.

Dr. Jackman recently joined ENT and Allergy Associates as a member of their Advanced Sinus/Skull Base Center following eight years as a clinical instructor and assistant professor at the hospitals of the University of Pennsylvania and Montefiore Medical Center/Albert Einstein College of Medicine.

Table Of Contents

Foreword by Peter H. Hwang, MD

Chapter 1. Fundamentals of Immunity
Denisa E. Ferastraoaru, Robert Tamayev, and Harris Goldstein

Chapter 2. Immunological Hypersensitivity Reactions
Denisa E. Ferastraoaru, Manish Ramesh, and David L. Rosenstreich

Chapter 3. Skin Testing and Laboratory Evaluation of Hypersensitivity
Gabriele S. de Vos and Joseph E. Jones

Chapter 4. Genetics of Allergic Disorders
C. Doriene van Ginkel, Anthony E.J. Dubois, and Gerard H. Koppelman

Chapter 5. Rhinitis and Rhinosinusitis
Judd H. Fastenberg and Alexis H. Jackman

Chapter 6. Asthma, Pulmonary Diseases, and Vocal Cord Dysfunction
Sunit Jariwala, Sumita Sinha, and Deepa Rastogi

Chapter 7. Urticaria and Angioedema
Luz Fonacier and Mark Davis-Lorton

Chapter 8. Drug Hypersensitivity
Juliane A. Pichler, Marco D. Caversaccio, and Werner J. Pichler

Chapter 9. Anaphylaxis and Mast Cell Disorders
Gabriele S. de Vos and Marianne Frieri

Chapter 10. Allergic Skin Diseases
Luz Fonacier, Melanie Chong, Ryan Steele, and Marcella R. Aquino

Chapter 11. Food Allergy and Food-Related Disorders
Antonella Cianferoni, Laura M. Gober, and Jonathan M. Spergel

Chapter 12. Environmental and Occupational Allergies
Kristin Schmidlin and Jonathan A. Bernstein

Chapter 13. Rheumatic Diseases and Vasculitides
Jennifer Guttman, Irene Blanco, and Clement E. Tagoe

Chapter 14. Tumor Immunology
Thomas J. Ow and Missak Haigentz, Jr.

Chapter 15. Primary Immunodeficiency
Tatyana Gavrilova and Arye Rubinstein

Chapter 16. Acquired Immune Deficiencies
Jasmeen S. Dara, Arye Rubinstein, and Jenny Shliozberg

Chapter 17. Allergen Immunotherapy
Ma. Lourdes B. de Asis and William R. Reisacher

Chapter 18. Immunomodulator Therapies: Monoclonal Antibodies, Fusion Proteins, and Immunoglobulins
Anna Rossovsky Smith and Larry Borish


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