About The Book

This authoritative text presents the background, methodology and outcomes for Photodynamic Therapy (PDT) treatment of diseases of the head and neck. The author, an expert and pioneer in this field, discusses the indications for PDT treatment with their advantages and pitfalls. As PDT is an approved therapy for treatment of head and neck cancers in many countries in the world, this text provides the clinician and basic researcher with an understanding of PDT and how to successfully employ it for the successful treatment of head and neck cancers. This comprehensive book is unique in that no other scientific text has devoted itself to the presentation of PDT treatment of head and neck and upper aerodigestive tract disease, a treatment area that has its own unique treatment issues.

This is the first text for clinicians and researchers who need to perform or learn about PDT of the head and neck. The text includes both established treatment modalities as well as new and upcoming treatments, such as the use of PDT to treat antibiotic resistant infections.

About The Author

Dr. Merrill Biel is also an associate clinical professor in the departments of surgery, otolaryngology, and family practice and a clinical professor in the School of Veterinary Medicine at the University of Minnesota. Dr. Biel has been involved in the preclinical and clinical applications of photodynamic therapy in head and neck cancer since 1987. He has been the principal investigator on an international multi-institutional trial of photodynamic therapy in the treatment of head and neck cancer and has treated over 400 patients with head and neck cancer using PDT, the largest single series of PDT treatment for head and neck cancer in the world. He is considered one of the world’s leading experts in the clinical use of photodynamic therapy for cancer treatment and is actively involved in the preclinical and clinical evaluation of new photosensitizers for the treatment of head and neck cancers. Dr. Biel has published over 25 manuscripts and 4 book chapters on pre-clinical and clinical applications of photodynamic therapy using various photosensitizers and laser systems. He has been a course director and guest faculty at numerous PDT training programs for physicians.

Table Of Contents

  1. The Roswell Park History of PDT: 1972 to the Present: A Personal Perspective
    Thomas J. Dougherty
  2. Principles of Photodynamic Therapy-Induced Killing of Tumor Cells
    Nancy L. Oleinick and David Kessel
  3. PDT Laser Physics and Safety
    Tom Mang
  4. Photodynamic Therapy (PDT) in Oral Cancer
    Barry L. Wenig and David Goldenberg
  5. Photodynamic Therapy of Early Laryngeal Cancer
    Merrill A. Biel
  6. Interstitial PDT Cancer Treatment
    Christian S. Betz and Colin Hopper
  7. Intraoperative Adjuvant PDT of Head and Neck Cancer
    Merrill A. Biel
  8. Photodynamic Therapy (PDT) in Nasopharyngeal Cancer
    I. B. Tan, H. J. Nyst, H. J. C. M. Sterenborg, R. L. P. van Veen, P. C. Levendag, D. J. Robinson, and F. A. Stewart
  9. Photodynamic Therapy for Esophageal Diseases
    Wetske M. Wystra and Kenneth K. Wang
  10. The Use of Photodynamic Therapy in the Management of Lung Cancer
    Eric S. Edell
  11. Photodynamic Therapy in Skin Cancer of the Head and Neck
    Alexander Kübler and Nicolas Hunzelmann
  12. Nursing Care of the Photodynamic Therapy (PDT) Head and Neck Patient
    Carla Kane
  13. Photodynamic Therapy of Recurrent Respitory Papillomatosis
    Mark J. Shikowitz, Bettie M. Steinberg, and Virginia Mullooly
  14. PDT of Bacterial and Fungal Biofilms
    Merrill Biel
  • Glossary of Terms
  • Appendices
    • 1. PDT Laser Treatment Record
    • 2. Formulae for Light Dose


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